certainly a step in the therapy of pain control and inflammation in medicine, have been the discovery of nonsteroidal antiinflammatory drugs Selective inhibition of ciclooxigenasa2 (Aines COX2 inhibitors).
The principle of these drugs is the inhibition of the important part of the cascade of inflammation, inhibition of cyclooxygenase-2, without altering or trying not to inhibit cyclooxygenase 1 (present in the gastrointestinal tract, the membrane of platelets and kidneys).
cox1 When inhibited, the side effects occurred as nonselective NSAIDs known as Aspirin. Gastrointestinal intolerance problems, kidney problems and blood clotting problems as enhance fibrinolysis.
When selectively inhibits COX2 these problems are minimal. Addition are leading a breakthrough in the treatment of certain types of cancer, as has been demonstrated by studies that COX2 inhibition can reduce the rate of growth of some tumors that express COX2. It is also based on antiangiogenic therapy. However
. Are any benefits?. For although initially if there is a small problem that must be considered, at least studied in human medicine (vetandpet unknown so far if serious studies show otherwise in veterinary medicine, so we rely on these human studies). The selective COX2 inhibition enhances the possibility of producing vascular thrombosis and increased systemic stress. This should be taken into consideration in patients with cardiovascular problems in which vascular stasis and activation of coagulation factors may increase the risk of thrombosis.
To see an interesting article of cox2 inhibitors (click here and download)
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